Tutorial of IWMPI 2019

Lecture 1: Introduction into MPI Instrumentation and Image Reconstruction

Jochen Franke, Product Manager Magnetic Particle Imaging, System Engineering & Integration, Bruker BioSpin MRI, Germany

The scope of the first part of this tutorial is to present an overview of signal generation and spatial encoding schemes used nowadays in Magnetic Particle Imaging. State-of-the-art MPI scanner topologies will be identified ranging from classical Field-Free-Point and Field-Free-Line systems to single-sided, traveling-wave and hybrid imaging systems. A brief description of magnetic field components with their field requirements and their functionality will be highlighted. With the help of block diagrams, MPI system components of classical signal chains will be described and characterized.

The second part of this tutorial covers the basic introduction of state-of-the-art reconstruction techniques used in Magnetic Particle Imaging. At most, the differences and similarities between the frequency- and time-space reconstruction approach will be addressed. With this overview, advanced techniques such as enlarged field of view or multi-color reconstruction will be discussed. Model-based reconstruction approaches and the usage of complementary information from other modalities will lead to the outlook and discussion section.

For all topics addressed during this tutorial, scientific papers will be highlighted to provide in-depth training material.

Jochen Franke studied Engineering Physics and Biomedical Engineering at the University of Applied Sciences Münster (Germany) and the Technical University RWTH Aachen (Germany). His PhD on “MPI-MRI hybrid imaging systems” he performs at Bruker BioSpin MRI, Ettlingen (Germany) and the Technical University RWTH Aachen (Germany). In 2016 Jochen became the Group Leader MPI Systems and Integration and in 2018 the Product Manager MPI Systems at Bruker BioSpin MRI, Ettlingen (Germany).

Lecture 2: Introduction into Magnetomotion

Klaas Bente, German Federal Institute for Materials Research and Testing (BAM), Germany

Many motile microorganisms swim and navigate in chemically and mechanically complex environments, such as the human vascular system. These organisms can be functionalized and directly used for applications (biohybrid approach), but also inspire designs for fully synthetic microbots. The most promising designs of biohybrids and bioinspired microswimmers include one or several magnetic components, which lead to sustainable propulsion mechanisms and external controllability.

This tutorial addresses such magnetic microswimmers, which are often studied in view of certain applications, mostly in the biomedical field. First, propulsion systems at the microscale are reviewed and the magnetism of microswimmers is introduced. The presentation of state-of-the-art magnetic biohybrids and bioinspired microswimmers is structured gradually from mostly biological systems toward purely synthetic approaches. Finally, currently less explored aspects of this field ranging from in vivo imaging to swarm control are discussed.

Klaas Bente studied Medical Engineering Science and did his PhD on real-time field-free line MPI at the Institute of Medical Engineering at the University of Lübeck, Germany, in 2016. Thereafter, he worked as a postdoc at the Max Planck Institute of Colloids and Interfaces in Potsdam, Germany, focusing on magnetic microswimmer imaging. He now works as a scientist on ultrasound imaging at the German Federal Institute for Materials Research and Testing (Bundesanstalt für Materialforschung und -prüfung, BAM), Berlin, Germany.

Lecture 3: MPI Application Review in Diagnostics, Monitoring and Therapy

Steve Conolly, Professor of Bioengineering and Electrical Engineering and Computer Sciences, UC Berkeley, USA;
Patrick Goodwill, Chief Technical Officer, Magnetic Insight, USA

MPI research has expanded beyond hardware and groups are now working on applying MPI to solve problems in scientific research and medicine.

In the first half of this tutorial we discuss some of the latest animal research being tested on MPI systems around the world. These applications span immune and cell tracking, cancer imaging, brain perfusion imaging, gut bleed detection, and lung ventilation-perfusion imaging.

In the second half of this tutorial, we discuss combined MPI/RF hyperthermia. In traditional RF hyperthermia, the application of high frequency, high amplitude magnetic fields heats up nanoparticles in the sample. The heating can have myriad applications including heating tumors to therapeutic temperatures and releasing payloads of interest such as drugs. We discuss how combining RF hyperthermia with MPI gives new opportunities, including spatial control of the heating to millimeter-scales, and real-time monitoring of the therapeutic heat dose.

Steve Conolly is a Professor of Bioengineering and Electrical Engineering and Computer Sciences at UC Berkeley, where he holds the Montford G. Cook Endowed Chair. He was elected Chair of the UC Berkeley-UCSF Joint Graduate Group in Bioengineering from 2006-2009. He currently serves as Vice Chair of Instruction in BioE at UC Berkeley. Dr. Conolly specializes in medical imaging and biosensing hardware, with a focus on Magnetic Particle Imaging and Magnetic Resonance Imaging. Prof. Conolly received his B.S in Electrical Engineering from Boston University, and his M.S. and Ph.D. in Electrical Engineering from Stanford University. Dr. Conolly has 30 patents in various stages of approval, and more than half of these have been licensed by industry.

Patrick Goodwill is the Chief Technical Officer at Magnetic Insight, Inc. In his role at the company, he is responsible for development of the MOMENTUM MPI imager, the first self-shielded commercial MPI system. Previously, he developed multiple generations of MPI imagers as a research scientist advised by Prof. Conolly. Dr. Goodwill received his B.S. and M.S. in Electrical Engineering from Stanford University, and a Ph.D. in Bioengineering from UC Berkeley.

The schedule of IWMPI 2019 is continuously updated.