9th International Workshop on Magnetic Particle Imaging

New York, USA | 2019, March 17 - 19


Thank you all for a great workshop IWMPI2019 with inspiring conversations, interesting talks and innovative posters. We hope you all returned back home safe and sound with plenty of new ideas.

The 9th IWMPI took place at the New York University (NYU) Langone Health, USA on March 17 - 19, 2019.

Scientific Program

Sunday, March 17, 2019

TimeSession
from 11:15Registration

12:00 - 15:00

Tutorial
Chair: T. Buzug

Lecture 1: Introduction into MPI Instrumentation and Image Reconstruction
Jochen Franke, Product Manager Magnetic Particle Imaging, System Engineering & Integration, Bruker BioSpin MRI, Germany

Lecture 2: Introduction into Magnetomotion
Klaas Bente, German Federal Institute for Materials Research and Testing (BAM), Germany

Lecture 3: MPI Application Review in Diagnostics, Monitoring and Therapy
Steve Conolly, Professor of Bioengineering and Electrical Engineering and Computer Sciences, UC Berkeley, USA; Patrick Goodwill, Chief Technical Officer, Magnetic Insight, USA

15:30 - 16:00

Workshop Opening - Welcome Speeches

Youssef Zaim Wadghiri; Director of Preclinical Imaging; NYU School of Medicine – NYU Langone Health       
N.N.; N.N.

16:00 - 17:30

Session 1: Instrumentation I
Chairs: Y. Z. Wadghiri, M. Magnani


A Field-Free Line Magnetic Particle Imager for Functional Neuroimaging in Rodents
E. E. Mason, E. Mattingly, J. Franke, S. M. Bradley, C. Z. Cooley, and L. L. Wald

Dynamic 2D Imaging with an MPI Scanner Featuring a Mechanically Rotated FFL
A. von Gladiss, J. Beuke, M. Weber, A. Malhotra, A. Behrends, A. Cordes, M. Stille, V. Behr, P. Vogel, K. Gräfe, Th. Friedrich, K. Lüdtke-Buzug, A. Neumann, M. Ahlborg, and T. M. Buzug

Design of a Preclinical Field Free Point/Field Free Line Hybrid MPI Scanner
A. R. Cagil and E. U. Saritas

MPI meets CT: first hybrid MPI-CT scanner
P. Vogel, J. Markert, M. A. Rückert, S. Herz, B. Keßler, K. Dremel, D. Althoff, M. Weber, T. M. Buzug, T. A. Bley, W. H. Kullmann, R. Hanke, S. Zabler, and V. C. Behr

1D Multi-Frequency MPI by passive and active Drive Field Feed-Through Compensation
D. Pantke, N. Holle, A. Mogarkar, S. Reinartz, and V. Schulz

Magnet Assembly Design for a Human-Scale Functional Magnetic Particle Imager (fMPI)
E. E. Mason, E. Mattingly, C. Z. Cooley, and L. L. Wald

First human-sized Magnetic Particle Imaging Device for Cerebral Applications
M. Graeser, F. Thieben, P. Szwargulski, F. Werner, N. Gdaniec, M. Boberg, F. Griese, M. Möddel, P. Ludewig, D. van de Ven, O. M. Weber, O. Woywode, B. Gleich, and T. Knopp

17:30 - 18:00

Keynote
Chair: Y. Z. Wadghiri

MPI:  The Future of Biomedical Molecular Imaging?
Peter Caravan, Martinos Center for Biomedical Imaging, Massachusetts General Hospital; Boston

MPI shows great optimism for molecular imaging: potentially low cost device, shelf-stable molecular probes, no ionizing radiation, direct detection of the probe, and relatively high sensitivity for detection. Drawing upon other modalities, this lecture will describe the requirements for successful MPI applications.  The ultimate utility of MPI is somewhat bounded by the need to utilize nanoparticle-based probes which are limited in their pharmacokinetic properties and biodistribution.  Acknowledging and working within these constraints still leaves a broad field of impactful application.  Here we will describe possible avenues for molecular probes that take advantage of this powerful emerging technology.

18:00 - 19:30

Get Together with small warm-up drink to prepare you for  St. Patricks Day in New York.

Monday, March 18, 2019

TimeSession

9:00 - 10:25

Session 2: Reconstruction, Theory, and Nanoparticle Physics I
Chairs: S. Conolly, F. Wiekhorst

Fast temporal regularized reconstructions for magnetic particle imaging
C. Brandt and A. Hauptmann

Spatio-temporal concentration reconstruction using motion priors in magnetic particle imaging
T. Kluth, B. N. Hahn, and C. Brandt

Experimental study on MPI motion artefacts
M. Bujotzek, H. Lehr, T. Schwaba, D. Gann, J. Franke, and U. Heinen

Multi-Patch Magnetic Particle Imaging of a Phantom with Periodic Motion
N. Gdaniec, P. Szwargulski, M. Möddel, M. Boberg, and T. Knopp

Pulsed MPI for Improved Resolution and Contrast
D. Hensley, Z. W. Tay, B. Zheng, J. Ma, N. O. Booijink, P. Chandrasekharan, P. Goodwill, and S. Conolly

Low Rank Approach to Sparse System Matrix Recovery for MPI
M. Grosser and T. Knopp

Background Removal by Mixing Factor based Filtering of the System Matrix
F. Lieb and H.-G. Stark

10:30 - 11:30

Poster Session 1

P01 Interpretation of Cartesian Data based on a Simulated Human-Sized MPI Brain Imager
P. Szwargulski, M. Graeser, F. Thieben, N. Gdaniec, F. Werner, M. Boberg, F. Griese, M. Möddel, and T. Knopp

P02 Neural Network for Reconstruction of MPI Images
P. Koch, M. Maass, M. Bruhnsa, C. Droigk, T. J. Parbs, and A. Mertins

P03 Determining the Relation between Iron Mass and Spatial Resolution for a Human-Sized Magnetic Particle Brain Imager
F. Thieben, M. Graeser, M. Boberg, P. Szwargulski, M. Moeddel, and T. Knopp

P04 Rapid PCI: An Alternative X-space Based Image Reconstruction for Rapid Scanning Trajectories
S. Kurt, M. Utkur, Y. Muslu, and E. U. Saritas

P05 A Super-Resolution Network for MPI
A. Ö. Arol, A. A. Ozaslan, S. Kurt, T. Çukur, and E. U. Saritas

P06 First MPS MObile Universal Surface Explorer
P. Vogel, M. A. Rückert, V. C. Behr

P07 Combined Active and Passive Cancellation of Receive Chain Direct Feedthrough
J. Beuke, K. Brandt, A. Malhotraa, A. Behrends, T. Friedrich, K. Gräfe, P. Rostalski, and T. M. Buzug

P08 Verification of the Linear System Response of a Single-Sided MPI Device
Y. Blancke Soares, K. Gräfe, A. von Gladiss, C. Debbeler, K. Lüdtke-Buzug, and T. M. Buzug

P09 Towards resolution phantoms for multi-centric comparison of instrumentation
O. Kosch, M. Graeser, J. Wells, P. Radon, H. Paysen, T. Knopp, and F. Wiekhorst

P10 Towards particle independent calibration of magnetic particle spectrometers: Initial experiments
F. Fidler, K.-H. Hiller, and P. M. Jakob

P11 Statistical Significance in Thrombus Characterization Using Magnetic Nanoparticle Spectroscopy of Brownian RotationJ. B. Weaver, H. Khurshid, C. V. Weaver, S. W. Gordon-Wylie, D. Ness, Y. Shi, D. A. Schartz, E. Demidenko, W. Wells, and C. J. Eskey

P12 A Schematic Kidney Phantom for Magnetic Particle Imaging
M. Schauerte, P. Szwargulski, M. G. Kaul, T. Knopp, and M. Graeser

P13 Multi-modality Imaging of Prostate Cancer in Mice using Magnetic Particle Imaging, Magnetic Resonance Imaging and Near-infrared ImagingH. You, W. Shang, H. Hui, X. Yang, J. Tian, and L. Wang

P14 System matrix dependent image quality of SPION infused polycaprolactone
H. Nilius, R. Siepmann, M. Orth, K. Mueller, F. Mueller, S. M. Dadfar, M. Darguzyte, V. Schulz, and S. D. Reinartz

P15 Evaluation of two iron oxide nanoparticle systems for their capabilities in MRI and MPI
S. Lyer, M. Liebl, H. Unterweger, O. Kosch, R. Tietze, E. Schreiber, T. Bäuerle, M. Uder, A. Dörfler, F. Wiekhorst, and C. Alexiou

P16 Estimation of M-H curve of NMPs using optimization technique
S. M. Choi, J.C. Jung, and H.B. Hong

P17 Effects of heating on tissue – safety limits and therapeutic aspects for MPI
U. Grzyska, F. Wegner, and J. Barkhausen

11:30 - 12:55

Session 3: Reconstruction, Theory, and Nanoparticle Physics II
Chairs: L. Wald, U. Haefeli

Magnetic Field Based Similarity Measure for System Matrices in Magnetic Particle Imaging
M. Boberg, T. Knopp, and M. Möddel

Harmonic Dispersion X-Space MPI
S. Kurt, M. Utkur, Y. Muslu, and E. U. Saritas

Discontinuous Kernels for the Reconstruction of Magnetic Particle Distributions with Jump Discontinuities
S. De Marchi, W. Erb, F. Marchetti, and E. Perracchione

Parameter estimations of magnetic particles: A comparison between measurements and simulations
A. Neumann, S. Draack, F. Ludwig, and T. M. Buzug

Core and hydrodynamic sizes dependence of harmonic signal in blood-pooling magnetic nanoparticles
S. Ota , Y. Ichikawa, I. Kato, S. Nohara, and Y. Takemura

Observation of correlated magnetic particle imaging and magnetic hyperthermia metrics in iron oxide nanoparticles
P. Southern , J. Wells, U. Steinhoff, F. Wiekhorst, C. Jonasson, C. Johansson, and Q. A. Pankhurst

Nanoparticle core size optimization for MPI
C. Shasha, E. Teeman, and K. M. Krishnan

13:00 - 14:00

Lunch Session
Chair: T. Buzug

Live MPI Demo and Lunch - Magnetic Insight
Join us for lunch right after the morning session to view the operation of the MOMENTUM MPI system live in New York. Dr. Patrick Goodwill will remotely demonstrate the MOMENTUM scanner live in real-time from the stage. Located at MSU’s new Institute for Quantitative Health Sciences and Engineering, this state-of-the-art research facility brings together engineers and basic science researchers with medical researchers to help solve some of the world’s biggest challenges. Take advantage of the opportunity to gain insight on the current development of MPI technology and an overview of ongoing projects around the world!

14:15 - 15:30

Session 4: Application I
Chairs: J. Bulte, Q. Pankhurst

White Blood Cell Tracking with Magnetic Particle Imaging: Towards Sensitive and Radiation-Free Diagnosis of Infection and Inflammation
X. Y. Zhou, P. Chandrasekharan, D. Mai, K. E. Jeffris, E. Y. Yu, B. Zheng, and S. M. Conolly

Filling in the voids left by Cellular MRI
A.V. Makela, J.M. Gaudet, C.H. Contag, and P.J. Foster

Virtual Brain Electrode (VIBE): Selective Magnetic Manipulation of Blood Conductivity
G. Philips, B. Gleich, G. A. Paredes-Juarez, A. Antonelli, M. Magnani, and J. W. M. Bulte

Dynamic Multi-Contrast Imaging of Two Different Tracer Materials in a Healthy Mouse
P. Szwargulski, P. Ludewig, M. Graeser, M. Möddel, N. Gdaniec, K. M. Krishnan, H. Ittrich, G. Adam, T. Magnus, and T. Knopp

Functional Magnetic Particle Imaging of Magnetic Nanoparticles in a Cellular Environment
H. Paysen, N. Loewa, O. Kosch, A. Stach, T. Schaeffter, A. Ludwig, and F. Wiekhorst

Sub-second bolus injection for increasing local sensitivity during the first pass of magnetic particle imaging
M. G. Kaul, T. Mummert, J. Salamon, C. Jung, M. Graeser, T. Knopp, G. Adam, and H. Ittrich

15:30 - 16:45

Poster Session 2

P18 Dynamic imaging of particle properties in 2D multi-spectral Magnetic Particle Imaging
T. Viereck , S. Draack , M. Schilling , and F. Ludwig

P19 FISTA reconstruction with particle derived filtering for Isotropic 3D FFL images in MPI
R. Orendorff, K. Lu, P. Pandit, Y. Zhang, J. Konkle, D. Hensley, E. Yu, R. B. Kettlewell, M. Weber, J.M. Gaudet, M. Wintermark, S. Conolly, and P. Goodwill

P20 Wrestling the Devil of Wasting Time: MPI System Matrix Recovery by Deep Learning
I. M. Baltruschat, F. Griese, P. Szwargulski, R. Werner, and T. Knopp

P21 A Strategy for the Extension of the Kaczmarz Algorithm to Different Priors
M. Maass, C. Droigk, P. Koch, and A. Mertins

P22 Multiresolution Magnetic Particle Imaging of Vessel Structures with Support Detection
C. Droigk, M. Maass, P. Koch, A. Möller, and A. Mertins

P23 Image Reconstruction Method of Magnetic Particle Imaging Using Orthogonality of Singular Value Decomposition
Y. Ono and Y. Ishihara

P24 A self-compensating coil setup for combined magnetic particle imaging and magnetic fluid hyperthermia
A. Behrends, H. Wei, T. Friedrich, A. Neumann, and T. M. Buzug

P25 A Concept for an Adjustable MPI System with Permanent Magnets
A. C. Bakenecker, J. Beuke, P. Blümler, A. von Gladiss, Th. Friedrich, and T. M. Buzug

P26 Sequential scanning of larger objects without focus field
V. Herynek, P. Francová, and L. Šefc

P27 Long-term Stability Analysis of a Preclinical Magnetic Particle Imaging System
H. Paysen, O. Kosch, J. Wells, T. Schaeffter, U. Steinhoff, and F. Wiekhorst

P28 Displacement Measurement for New MPI System Based on Vibrating Magnetic Nano Particles
K. Moriwaki and Y. Ishihara

P29 Development of a simulation model for magnetic nanoparticle imaging using ultrasonic vibration
M. Watanabe, S. Urushibata, and Y. Ishihara

P30 Electron Paramagnetic Resonance and Magnetic Particle Imaging: perspectives for co-imaging
M. Tseytlin, A. Bobko, and O. Tseytlin

P31 Improvement of Sensitivity and Spatial Resolution in Magnetic Particle Imaging Using Fractionated Magnetic Particles
T. Yoshida, T. Nakamura, O. Higashi, Y. Noguchi, and K. Enpuku

P32 System function analysis for estimation of MPI tracer resolution without phantom measurement
O. Kosch, J. Wells, H. Paysen, and F. Wiekhorst

P33 Engineered Protein‐Iron Oxide Hybrid Biomaterial as Magnetic Imaging‐traceable Drug Delivery
K. Punia, L. K. Hill, J. A. Tranos, Z. B. Youss, T. Jihad, J. M. Gaudet, X. Xie, E. Delago‐Fukushima, C. F. Liu, J. K. Montclare, and Y. Z. Wadghiri

P34 Spectral Decomposition of Particle Mobility in Magnetic Particle Spectroscopy
S. Draack, M. Schilling, F. Ludwig, and T. Viereck

P35 Sentinel node procedure in prostate and bladder cancer utilizing Differential Magnetometry: A first patient trial
L. Molenaar, M.M. van de Loosdrecht, J. van Baarlen, I.A.M.J. Broeders, B. ten Haken, and H. Roelink

P36 Stroke Detection using Magnetic Particle Imaging: A Phantom Study using a Human-sized Brain Phantom
F. Werner, M. Gräser, F. Thieben, P Szwargulski, N. Gdaniec, M. Boberg, F. Griese, M. Möddel, P. Ludewig, D. van de Ven, O. M. Weber, O. Woywode, B. Gleich, and T. Knopp

P37 Development of a dynamic bolus phantom system for magnetic particle imaging
A. Stang, L. Wöckel, O. Kosch, P. Vogel, J. Wells, V. C. Behr, C. Grüttner, F. Wiekhorst, and S . Dutz

P38 Evaluation of migration timespan of SPION with MPS and AAS within a healthy mouse model for sentinel lymph node detection in breast cancer
L. Sydow, K. Lüdtke-Buzug, A. Rody, T. M. Buzug, and D. Finas

P39 Tracer Temperature During MPI-frequency magnetic field excitation
J. Wells, O. Kosch, H. Paysen, and F. Wiekhorst

16:45 - 18:00

Session 5: Application II
Chairs: K. Murase, T. Knopp

Determining Perfusion Parameters using Magnetic Particle Imaging: A Phantom Study using a Human-Sized Flow Phantom
N. Gdaniec, M. Graeser, F. Thieben, P Szwargulski, F. Werner, M. Boberg, F. Griese, M. Möddel, P. Ludewig, D. van de Ven, O. M. Weber, O. Woywode, B. Gleich, and T. Knopp

Artifact-Free Imaging of the In-Stent Lumen of Coronary Stents with MPI – A Proof of Concept
F. Wegner, T. Friedrich, A. von Gladiss, U. Grzyska, T. M. Buzug, J. Barkhausen, and J. Haegele

Interventional Devices Tailored for MPI
Th. Friedrich, M. Ahlborg, A. von Gladiss, D. Bohsung, C. Moers, T. Göttsche, C. Weiß, F. Wegner, and T.M. Buzug

Hyperthermia and Imaging Performance of Hybrid Implant Materials
B. Mues, F. Jiang, B. Bauer, P. Radon, F. Wiekhorst, T. Schmitz-Rode, and I. Slabu

Simultaneous Actuation and Visualization of a Magnetically Coated Swimmer with MPI
A. C. Bakenecker, A. von Gladiss, M. Herbst, H. Lehr, M. Graeser, M. Ahlborg, Th. Friedrich, and T. M. Buzug

Percutaneous transluminal angioplasty (PTA): MPI vs. X-ray guidance
S. Herz, P. Vogel, T. Kampf, P. Dietrich, M. A. Rückert, R. Kickuth, V. C. Behr, and T. A. Bley

18:00 - 18:10

Editor's Session: quo vadis IJMPI
T. Knopp

18:10 - 19:00

Footwalk to Pier: Skyport Marina and Boarding

19:00

Cruise

Tuesday, March 19, 2019

TimeSession

9:00 - 10:15

Session 6: Synthesis and Spectroscopy
Chairs: A. Samia, S. Dutz

Aqueous micromixer synthesis to gain reproducible, high performance MPI tracers
A. Baki, N. Löwa, C. Knopke, S. G. Diamond, O. Kosch, F. Wiekhorst, and R. Bleul

Suspensions of sub-micron microfabricated magnetic discs
L. Abelmann, A.-R. Blaudszun, H. van Wolferen, K. Ma, and P. A. Löthman

Effect of dextran on the nucleation and growth of nanostructures with an In-situ Magnetic Particle Spectrometer (INSPECT)
A. Malhotra, A. von Gladiss, T. M. Buzug, and K. Lüdtke-Buzug

Intracellular dynamics of superparamagnetic iron oxide nanoparticles for MPI
E. Teeman, C. Shasha, J. E. Evans, and K. M. Krishnan

Magnetic nanoparticles based binding imaging with a scanning magnetic particle spectrometer
J. Zhong, M. Schilling, and F. Ludwig

One-Dimensional Multi-Frequency Spectrometer
C. Knopke, B.W. Ficko, and S. G. Diamond

10:20 - 11:20

Poster Session 3

P40 An Inline Reconstruction Technique for MPI
A. Cordes, and T. M. Buzug

P41 MPI using sub-voxel focus field offsets
M. Herbst, H. Lehr, and J. Franke

P42 Multi-parametric image reconstruction in Magnetic Particle Imaging
N. C. Holle, D. Pantke, S. Reinartz, A. Mogarkar, and V. Schulz

P43 Selection-Field-Induced Warping in X-Space MPI
E. Yagiz, M. Ütkür, O. C. Eren, and E. U. Saritas

P44 A novelty 2-D temperature imaging method by scanning magnetic nanoparticles thermometer
Yi Sun , Zhongzhou Du , Dandan Wang, and Rijian Su

P45 Exploring parameters of magnetic particles in 1D field excitation
T. Klemme, T. M. Buzug, and A. Neumann

P46 3D printed magnetic composites as phantoms for Magnetic Particle Imaging
N. Löwa, H. Paysen, D. Gutkelch, and F. Wiekhorst

P47 A Low Cost 3D Printed Magnetic Particle Spectrometer for the Undergraduate Laboratory
J. L. Stafford, M. I. Newton, and R. H. Morris

P48 MPI Velocity Mapping in a coronary Vessel Phantom
R. Siepmann, H. Nilius, F. Mueller, K. Mueller, S. M. Dadfar, V. Schulz, and S. D. Reinartz

P49 Anatomical Rat Phantom for MPI
M. Exner, P. Szwargulski, P. Ludewig, T. Knopp, and M. Graeser

P50 Imaging full body biodistribution and signal properties of magnetic nanoflowers
J.M. Gaudet, R. Orendorff, C. Grüttner, Y. Zhang, M. Wintermark, H. Teller, and P.W. Goodwill

P51 Magnetically initiated remote controlled drug release from magnetic microspheres
D. Zahn, A. Weidner, Z. Nosrati, K. Saatchi, U.O. Häfeli, and S. Dutz

P52 Mechanical Design of a Human-Scale Magnetic Particle Imager for Functional Brain Imaging (fMPI)
E. Mattingly, E. E. Mason, C. Z. Cooley, and L. L. Wald

P53 Evaluation of FFP Performance in Halbach and Radial Permanent Magnet Systems
F. Balcı, N. Dogan, and A. Bingolbali

P54 MRI-based field of view selection for precise, real-time targeting in MPI
F. Griese, M. Prieske, M. Möddel, R. Werner, and T. Knopp

P55 Implementation of a Heating Coil Insert for a Preclinical MPI Scanner Designed Using DEPSO
H. Wei, A. Behrends, Th. Friedrich, and T. M. Buzug

P56 Sample Temperature Control in a Three-Dimensional Magnetic Particle Spectrometer
X. Chen, A. Behrends, A. Neumann, and T. M. Buzug

11:20 - 12:30

Session 7: Application III
Chairs: J. Weaver, E. Saritas


Monitoring Iron Oxide Nanoparticle Uptake in Plants with Magnetic Particle Spectroscopy
A.C.S. Samia

Generalizing In Vivo ELISA Spectroscopic Methods Using Antibody Targeted Nanoparticles
S.W. Gordon-Wylie, D.B. Ness, Y. Shi, S.G. Diamond, S.K. Mirza, and J.B. Weaver

synomag®: The New High-Performance Tracer for Magnetic Particle Imaging
P. Vogel, T. Kampf, M. A. Rückert, C. Grüttner, A. Kowalski, H. Teller, and V. C. Behr

Long-term stable multimodal solid-state measurement phantoms for quantitative magnetic particle imaging
L. Wöckel, O. Kosch, J. Wells, F. Wiekhorst, K.-H. Herrmann, J.R. Reichenbach, S. Günther, C. Grüttner, and S. Dutz

Confounding Effects of Temperature and Viscosity Towards Relaxation Mapping
M. Utkur and E. U. Saritas

Improved depth sensitivity by separation of excitation and detection coils
M.M. van de Loosdrecht, H.J.G. Krooshoop, and B. ten Haken

12:40 - 13:40

Lunch Session
Chair: T. Buzug

Bruker: Achievements of the MPI community – Time is of the essence
Take a break and enjoy lunch with us! We will give you a quick overview of the recent outstanding scientific achievements in the field of MPI. From real-time applications to image guided actuation, Jochen Franke will provide you a vivid summary of the latest results gathered on the Bruker MPI system.
Bruker is glad to relentlessly drive innovation for scientists, while our close collaboration with the very dynamic MPI community is the key success factor empowering MPI as one of the most promising imaging techniques for new spatially encoded theranostics approaches.
As time is of the essence, get inspired by our life science community recent achievements. Continue pioneering the fascinating field of Magnetic Particle Imaging technology together with us. Let’s pave new ways to personalized medicine and revolutionize clinical diagnostic and therapeutic routines.

13:50 - 14:50

Session 8: Instrumentation II
Chairs: A. Tonyushkin, U. Heinen

Feasibility of a spatial resolution enhancement by a passive dual coil resonator (pDCR) insert for large bore MPI systems
S. D. Reinartz , D. Pantke , A. Mogarkar, F. Mueller, and V. Schulz

Towards a Single-Sided FFL MPI Scanner for in vivo Breast Cancer Imaging
E. Mason and A. Tonyushkin

Dynamic Imaging with a 3D Single-Sided MPI Scanner
A. von Gladiss, Y. Blancke Soares, T. M. Buzug and K. Gräfe

Flow of Magnetic Nanoparticles detected by 2n Harmonic Responses using HTS SQUID Array
S. Tanaka, M. Kabasawa, and K. Hayashi

A Rabbit Sized Field-Free-Line Magnetic-Particle-Imaging Scanner – Past, Present, and Future
J. Stelzner, K. Gräfe, A. von Gladiss, J. Beuke, and T. M. Buzug

14:50 - 15:00

Wrap-up and Farewell
Y. Z. Wadghiri, T. Buzug, V. Behr

15:30

Lab Tour
Y. Z. Wadghiri et al.

Partners and Exhibitors

Endorsements

Details about Keynote and Tutorials

MPI:  The Future of Biomedical Molecular Imaging?

Peter Caravan, Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, USA

MPI shows great optimism for molecular imaging: potentially low cost device, shelf-stable molecular probes, no ionizing radiation, direct detection of the probe, and relatively high sensitivity for detection. Drawing upon other modalities, this lecture will describe the requirements for successful MPI applications. 

The ultimate utility of MPI is somewhat bounded by the need to utilize nanoparticle-based probes which are limited in their pharmacokinetic properties and biodistribution.  Acknowledging and working within these constraints still leaves a broad field of impactful application.  Here we will describe possible avenues for molecular probes that take advantage of this powerful emerging technology.  



Peter Caravan 
1997PhD in Chemistry, University of British Columbia
1998Post-doctoral fellow, Chemistry, Université de Lausanne
04/07-02/08          Instructor, Radiology, Harvard Medical School
02/08-09/13Assistant Professor, Radiology, Harvard Medical School
10/13 -   Associate Professor, Professor, Radiology, Harvard Medical School
2014 -Co-Director, Institute for Innovation in Imaging: Establish, direct, and manage translational imaging institute

Tutorial Lecture 1: Introduction into MPI Instrumentation and Image Reconstruction

Jochen Franke, Product Manager Magnetic Particle Imaging, System Engineering & Integration, Bruker BioSpin MRI, Germany

The scope of the first part of this tutorial is to present an overview of signal generation and spatial encoding schemes used nowadays in Magnetic Particle Imaging. State-of-the-art MPI scanner topologies will be identified ranging from classical Field-Free-Point and Field-Free-Line systems to single-sided, traveling-wave and hybrid imaging systems. A brief description of magnetic field components with their field requirements and their functionality will be highlighted. With the help of block diagrams, MPI system components of classical signal chains will be described and characterized.

The second part of this tutorial covers the basic introduction of state-of-the-art reconstruction techniques used in Magnetic Particle Imaging. At most, the differences and similarities between the frequency- and time-space reconstruction approach will be addressed. With this overview, advanced techniques such as enlarged field of view or multi-color reconstruction will be discussed. Model-based reconstruction approaches and the usage of complementary information from other modalities will lead to the outlook and discussion section.

For all topics addressed during this tutorial, scientific papers will be highlighted to provide in-depth training material.



Jochen Franke studied Engineering Physics and Biomedical Engineering at the University of Applied Sciences Münster (Germany) and the Technical University RWTH Aachen (Germany). His PhD on “MPI-MRI hybrid imaging systems” he performs at Bruker BioSpin MRI, Ettlingen (Germany) and the Technical University RWTH Aachen (Germany). In 2016 Jochen became the Group Leader MPI Systems and Integration and in 2018 the Product Manager MPI Systems at Bruker BioSpin MRI, Ettlingen (Germany).

Tutorial Lecture 2: Introduction into Magnetomotion

Klaas Bente, German Federal Institute for Materials Research and Testing (BAM), Germany

Many motile microorganisms swim and navigate in chemically and mechanically complex environments, such as the human vascular system. These organisms can be functionalized and directly used for applications (biohybrid approach), but also inspire designs for fully synthetic microbots. The most promising designs of biohybrids and bioinspired microswimmers include one or several magnetic components, which lead to sustainable propulsion mechanisms and external controllability.

This tutorial addresses such magnetic microswimmers, which are often studied in view of certain applications, mostly in the biomedical field. First, propulsion systems at the microscale are reviewed and the magnetism of microswimmers is introduced. The presentation of state-of-the-art magnetic biohybrids and bioinspired microswimmers is structured gradually from mostly biological systems toward purely synthetic approaches. Finally, currently less explored aspects of this field ranging from in vivo imaging to swarm control are discussed.



Klaas Bente studied Medical Engineering Science and did his PhD on real-time field-free line MPI at the Institute of Medical Engineering at the University of Lübeck, Germany, in 2016. Thereafter, he worked as a postdoc at the Max Planck Institute of Colloids and Interfaces in Potsdam, Germany, focusing on magnetic microswimmer imaging. He now works as a scientist on ultrasound imaging at the German Federal Institute for Materials Research and Testing (Bundesanstalt für Materialforschung und -prüfung, BAM), Berlin, Germany.

Tutorial Lecture 3: MPI Application Review in Diagnostics, Monitoring and Therapy

Steve Conolly, Professor of Bioengineering and Electrical Engineering and Computer Sciences, UC Berkeley, USA;
Patrick Goodwill, Chief Technical Officer, Magnetic Insight, USA

MPI research has expanded beyond hardware and groups are now working on applying MPI to solve problems in scientific research and medicine.

In the first half of this tutorial we discuss some of the latest animal research being tested on MPI systems around the world. These applications span immune and cell tracking, cancer imaging, brain perfusion imaging, gut bleed detection, and lung ventilation-perfusion imaging.

In the second half of this tutorial, we discuss combined MPI/RF hyperthermia. In traditional RF hyperthermia, the application of high frequency, high amplitude magnetic fields heats up nanoparticles in the sample. The heating can have myriad applications including heating tumors to therapeutic temperatures and releasing payloads of interest such as drugs. We discuss how combining RF hyperthermia with MPI gives new opportunities, including spatial control of the heating to millimeter-scales, and real-time monitoring of the therapeutic heat dose.



Steve Conolly is a Professor of Bioengineering and Electrical Engineering and Computer Sciences at UC Berkeley, where he holds the Montford G. Cook Endowed Chair. He was elected Chair of the UC Berkeley-UCSF Joint Graduate Group in Bioengineering from 2006-2009. He currently serves as Vice Chair of Instruction in BioE at UC Berkeley. Dr. Conolly specializes in medical imaging and biosensing hardware, with a focus on Magnetic Particle Imaging and Magnetic Resonance Imaging. Prof. Conolly received his B.S in Electrical Engineering from Boston University, and his M.S. and Ph.D. in Electrical Engineering from Stanford University. Dr. Conolly has 30 patents in various stages of approval, and more than half of these have been licensed by industry.

Patrick Goodwill is the Chief Technical Officer at Magnetic Insight, Inc. In his role at the company, he is responsible for development of the MOMENTUM MPI imager, the first self-shielded commercial MPI system. Previously, he developed multiple generations of MPI imagers as a research scientist advised by Prof. Conolly. Dr. Goodwill received his B.S. and M.S. in Electrical Engineering from Stanford University, and a Ph.D. in Bioengineering from UC Berkeley.